Abstract Title:

Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.).

Abstract Source:

Nat Prod Res. 2017 Aug 2:1-4. Epub 2017 Aug 2. PMID: 28768425

Abstract Author(s):

Jianteng Wei, Shuxian Wang, Dong Pei, Liangjing Qu, Ya Li, Jianjun Chen, Duolong Di, Kun Gao

Article Affiliation:

Jianteng Wei


Vibrio spp. are pathogens of many bacterial diseases which have caused great economic losses in marine aquaculture. The strategy of alternative medical treatment that is utilised by herbalists has expanded in the past decade. The aim of our study is to discover the antibacterial molecules against Vibrio spp. Bacterial growth inhibition, membrane permeabilisation assessment and DNA interaction assays, as well as agarose gel electrophoresis, were employed to elucidate the antibacterial activity of hydroxytyrosol acetate. Results showed that hydroxytyrosol acetate had antibacterial activity against Vibrio spp. and it played the role via increasing bacterial membrane permeabilisation. The DNA interaction assay and agarose gel electrophoresis revealed that hydroxytyrosol acetate interacted with DNA. Hydroxytyrosol acetate enhanced the fluorescent intensity of DNA binding molecules and mediated supercoiled DNA relaxation. The present study provides more evidence that hydroxytyrosol acetate is a novel antibacterial candidate against Vibrio spp.

Study Type : In Vitro Study

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