Abstract Title:

Prenatal PMexposure and neurodevelopment at 2 years of age in a birth cohort from Mexico city.

Abstract Source:

Int J Hyg Environ Health. 2021 Feb 11 ;233:113695. Epub 2021 Feb 11. PMID: 33582606

Abstract Author(s):

Magali Hurtado-Díaz, Horacio Riojas-Rodríguez, Stephen J Rothenberg, Lourdes Schnaas-Arrieta, Itai Kloog, Allan Just, David Hernández-Bonilla, Robert O Wright, Martha Ma Téllez-Rojo

Article Affiliation:

Magali Hurtado-Díaz


BACKGROUND: Recent studies have reported that air pollution exposure may have neurotoxic properties.

OBJECTIVE: To examine longitudinal associations between prenatal particles less than 2.5 μm in diameter (PM) exposure and neurodevelopment during the first two years of children's life.

METHODS: Analysis was conducted in PROGRESS, a longitudinal birth cohort between 2007 and 2013 in Mexico City. We used satellite data to predict daily PMconcentrations at high spatial resolution. Multivariate mixed-effect regression models were adjusted to examine cognitive, language and motor scores in children up to 24 months of age (n = 740) and each trimester-specific and whole pregnancy exposure to PM.

RESULTS: Models adjusted by child sex, gestational age, birth weight, smoking and mother's IQ, showed that each increase of 1 μg/mof PMwas associated with a decreased language function of -0.38 points (95% CI: -0.77, -0.01). PMexposure at third trimester of pregnancy contributed most to the observed association.

CONCLUSION: Our findings suggest that language development up to 24 months of age may be particularly sensitive to PMexposure during pregnancy.

Study Type : Human Study

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