Abstract Title:

Potential pancreatic lipase inhibitory activity of phenolic constituents from the root bark of Morus alba L.

Abstract Source:

Bioorg Med Chem Lett. 2016 Jun 15 ;26(12):2788-94. Epub 2016 Apr 23. PMID: 27156775

Abstract Author(s):

Manh Tuan Ha, Manh Hung Tran, Kim Jeong Ah, Kyung-Jin Jo, Jaewang Kim, Wook Dong Kim, Woo Jae Cheon, Mi Hee Woo, Sung Ho Ryu, Byung Sun Min

Article Affiliation:

Manh Tuan Ha


Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50=0.012μM), with IC50 values ranging from 0.09 to 0.92μM.

Study Type : In Vitro Study

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