Abstract Title:

Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda.

Abstract Source:

Cancer Epidemiol. 2018 Feb ;52:70-74. Epub 2017 Dec 14. PMID: 29248801

Abstract Author(s):

Ravell Juan, Isaac Otim, Hadijah Nabalende, Ismail D Legason, Steven J Reynolds, Martin D Ogwang, Christopher M Ndugwa, Vickie Marshall, Denise Whitby, James J Goedert, Eric A Engels, Kishor Bhatia, Michael J Lenardo, Sam M Mbulaiteye

Article Affiliation:

Ravell Juan


BACKGROUND: Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (eBL). EBV control was improved by magnesium (Mg2+) supplementation in XMEN, an X-linked genetic disease associated with Mg2+ deficiency, high circulating EBV levels (viral loads), and EBV-related lymphomas. We, therefore, investigated the relationship between Mg2+ levels and EBV levels and eBL in Uganda.

METHODS: Plasma Mg2+ was measured in 45 women with low or high circulating EBV levels, 40 pediatric eBL cases, and 79 healthy children. Mg2+ uptake by T-lymphocytes was evaluated in samples from healthy donors.

RESULTS: Plasma Mg2+ deficiency (plasma level<1.8 mg/dl) was more likely in women with high- vs. low-EBV levels (76.0% vs. 35%; odds ratio [OR] 11.3, 95% CI 2.14-60.2), controlling for age, and in eBL cases than controls (42.0% vs. 13.9%; OR 3.61, 95% CI 1.32-9.88), controlling for sex, age group, and malaria status. Mg2+ uptake by T-lymphocyteswas related to extracellular Mg2+ concentration.

INTERPRETATION: Plasma Mg2+ deficiency is associated with high EBV levels and eBL.

Study Type : Human Study

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