Abstract Title:

Piperine, an active ingredient of white pepper suppresses growth of multidrug resistant toxigenic Vibrio cholerae and other pathogenic bacteria.

Abstract Source:

Lett Appl Microbiol. 2022 Jan 3. Epub 2022 Jan 3. PMID: 34978719

Abstract Author(s):

Goutham Belagula Manjunath, Sharda Prasad Awasthi, M Shamim Hasan Zahid, Noritoshi Hatanaka, Atsushi Hinenoya, Emiko Iwaoka, Shunji Aoki, Thandavarayan Ramamurthy, Shinji Yamasaki

Article Affiliation:

Goutham Belagula Manjunath


Emergence and rapid spread of multi-drug resistant (MDR) bacteria including Vibrio cholerae are a global public health issue. Much attention has been paid to natural compounds, such as spices and herbs to find novel antimicrobial compounds as they are considered to be cheaper alternatives to develop as a drug. Here, we show that methanol extract of white pepper could inhibit growth of V. cholerae O1 El Tor variant, responsible for the recent outbreaks/epidemics. Furthermore, we demonstrate for the first time that piperine, the major component of white pepper showed a dose-dependent bactericidal effect on V. cholerae growth irrespective of their biotypes and serogroups in presence of 200 and 300µg mlof piperine, respectively. Piperine also inhibited growth of MDR strains of Pseudomonas aeruginosa, Escherichia coli isolated from poultry and enterohemorrhagic/enteroaggregative E. coli O104 in presence of 200µg ml. Interestingly, we did not observe any significant inhibitory effect of piperine on E. coli strains isolated from healthy person even up to 200µg ml. Our data suggest that piperine could be a novel antimicrobial agent in therapeutic and preventive applications against infections caused by pathogenic bacteria including MDR strains.

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