Article Publish Status: FREE
Abstract Title:

Oil as A Potential Treatment forWound Infection: In Vitro and In Vivo Bioassays in Relation to Its Chemical Composition.

Abstract Source:

Antibiotics (Basel). 2020 Oct 7 ;9(10). Epub 2020 Oct 7. PMID: 33036456

Abstract Author(s):

Maha M Ismail, Reham Samir, Fatema R Saber, Shaimaa R Ahmed, Mohamed A Farag

Article Affiliation:

Maha M Ismail


Bacterial biofilm contributes to antibiotic resistance. Developing antibiofilm agents, more favored from natural origin, is a potential method for treatment of highly virulent multidrug resistant (MDR) bacterial strains; The potential ofandessential oils (E.Os) antibacterial and antibiofilm activities in relation to their chemical composition, in addition to their ability to treatwound infection in mice model were investigated;leaf E.O at 0.05µg·mLefficiently inhibited and eradicated biofilm formed byby 85% and 34%, respectively. Bothandleaf E.Os showed a bactericidal action againstwithin 6h at 2.08µg·mL. In addition, a significant reduction ofmicrobial load in mice wound infection model was found. Furthermore, gas chromatography mass spectrometry analysis revealed qualitative and quantitative differences amongandleaf and berry E.Os. Monoterpene hydrocarbons, oxygenated monoterpenes, and phenolics were the major detected classes.β-Myrcene, limonene, 1,8-cineole, and eugenol were the most abundant volatiles. While, sesquiterpenes were found as minor components inberries E.O; Our finding suggests the potential antimicrobial activity ofleaf E.O against MDRwound infections and their underlying mechanism and to be further tested clinically as treatment for MDRinfections.

Study Type : Animal Study, In Vitro Study

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