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Article Publish Status: FREE
Abstract Title:

Pharmacodynamic substances in Salvia miltiorrhiza for prevention and treatment of hyperlipidemia and coronary heart disease based on lipidomics technology and network pharmacology analysis.

Abstract Source:

Biomed Pharmacother. 2021 Jul 2 ;141:111846. Epub 2021 Jul 2. PMID: 34225018

Abstract Author(s):

Guijiang Sun, Xiaomeng Li, Jinxia Wei, Tianpu Zhang, Bo Li, Meiling Chen, Yuming Wang, Kangyin Chen, Yubo Li

Article Affiliation:

Guijiang Sun

Abstract:

In this study, untargeted lipidomics based on UPLC-Q/TOF-MS, network pharmacology and atomic force microscopy were used to explore the common biomarkers of hyperlipidemia and coronary heart disease, the therapeutic mechanism of the main components of Salvia miltiorrhiza as well as the action mechanism of key lipids. Firstly, the serum samples of 30 healthy people, 30 patients with coronary heart disease and 30 patients with hyperlipidemia were analyzed by using lipidomics technology to obtain biomarkers which can be used to link hyperlipidemia and coronary heart disease and to find potential targets; then, the key components and core targets of Salvia miltiorrhiza intervention in hyperlipidemia and coronary heart disease were analyzed by network pharmacology, the results were verified by atomic force microscopy. It showed that SMS2 might be the key target. And through network pharmacology and atomic force microscope analysis, it can be inferred that salvianolic acid A can combine with SMS2 to play a therapeutic role.

Study Type : Human In Vitro, Human Study

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Sayer Ji
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