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Article Publish Status: FREE
Abstract Title:

PD-1-Expressing SARS-CoV-2-Specific CD8T Cells Are Not Exhausted, but Functional in Patients with COVID-19.

Abstract Source:

Immunity. 2021 01 12 ;54(1):44-52.e3. Epub 2020 Dec 14. PMID: 33338412

Abstract Author(s):

Min-Seok Rha, Hye Won Jeong, Jae-Hoon Ko, Seong Jin Choi, In-Ho Seo, Jeong Seok Lee, Moa Sa, A Reum Kim, Eun-Jeong Joo, Jin Young Ahn, Jung Ho Kim, Kyoung-Ho Song, Eu Suk Kim, Dong Hyun Oh, Mi Young Ahn, Hee Kyoung Choi, Ji Hoon Jeon, Jae-Phil Choi, Hong Bin Kim, Young Keun Kim, Su-Hyung Park, Won Suk Choi, Jun Yong Choi, Kyong Ran Peck, Eui-Cheol Shin

Article Affiliation:

Min-Seok Rha

Abstract:

Memory T cell responses have been demonstrated in COVID-19 convalescents, but ex vivo phenotypes of SARS-CoV-2-specific T cells have been unclear. We detected SARS-CoV-2-specific CD8T cells by MHC class I multimer staining and examined their phenotypes and functions in acute and convalescent COVID-19. Multimercells exhibited early differentiated effector-memory phenotypes in the early convalescent phase. The frequency of stem-like memory cells was increased among multimercells in the late convalescent phase. Cytokine secretion assays combined with MHC class I multimer staining revealed that the proportion of interferon-γ (IFN-γ)-producing cells was significantly lower among SARS-CoV-2-specific CD8T cells than those specific to influenza A virus. Importantly, the proportion of IFN-γ-producing cells was higher in PD-1cells than PD-1cells among multimercells, indicating that PD-1-expressing, SARS-CoV-2-specific CD8T cells are not exhausted, but functional. Our current findings provide information for understanding of SARS-CoV-2-specific CD8T cells elicited by infection or vaccination.

Study Type : Human Study

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Sayer Ji
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