Abstract Title:

Effect of palm oil carotene on breast cancer tumorigenicity in nude mice.

Abstract Source:

Lipids. 2002 Jun;37(6):557-60. PMID: 12120953

Abstract Author(s):

Kalanithi Nesaretnam, Ammu Radhakrishnan, Kanga Rani Selvaduray, Karin Reimann, Jayalakshmi Pailoor, Ghazali Razak, Mina Mustafa Mahmood, Jasbir Singh Dahliwal


Biological therapies are new additions to breast cancer treatment. Among biological compounds, beta-carotene has been reported to have immune modulatory effects, in particular, enhancement of natural killer cell activity and tumor necrosis factor-alpha production by macrophages. The objective of this study was to investigate the effect of palm carotene supplementation on the tumorigenicity of MCF-7 human breast cancer cells injected into athymic nude mice and to explore the mechanism by which palm carotenes suppress tumorigenesis. Forty-eight 4-wk-old mice were injected with 1 x 10(6) MCF-7 cells into their mammary fat pad. The experimental group was supplemented with palm carotene whereas the control group was not. Significant differences were observed in tumor incidence (P< 0.001) and tumor surface area and metastasis to lung (P< 0.005) between the two groups. Natural killer (NK) cells and B-lymphocytes in the peripheral blood of carotene-supplemented mice were significantly increased (P < 0.05 and P < 0.001, respectively) compared with controls. These results suggest that palm oil carotene is able to modulate the immune system by increasing peripheral blood NK cells and B-lymphocytes and suppress the growth of MCF-7 human breast cancer cells.

Study Type : Transgenic Animal Study
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