n/a
Article Publish Status: FREE
Abstract Title:

Novel anti-hepatitis B virus-active catechin and epicatechin from.

Abstract Source:

Exp Ther Med. 2022 Jun ;23(6):398. Epub 2022 Apr 15. PMID: 35619632

Abstract Author(s):

Mohammad K Parvez, Mohammed S Al-Dosari, Mazin A S Abdelwahid, Ali S Alqahtani, Abdullah R Alanzi

Article Affiliation:

Mohammad K Parvez

Abstract:

Bioactive natural or phytoproducts have emerged as a potential source of antiviral agents. Of thespp.,andhave been reported for their antiviral activities against hepatitis B virus (HBV), while the anti-HBV efficacy ofhas remained elusive. In the present study, the anti-HBV activities of-derived novel catechin [3,5,13,14-flavantetrol-catechin or rhuspartin (RPT)] and epicatechin-3--rhamnoside (ECR), were assessed using the HBV-reporter cell line HepG2.2.15. RPT and ECR proved to efficiently inhibit HBV surface antigen (HBsAg) synthesis by 68.8 and 71.3%, respectively, and HBV pre-core antigen (HBeAg) production by 62.3 and 71.2%, respectively, after 5 days of treatment. Of note, RPT had a lower anti-HBV activity than ECR. In comparison, the reference drug lamivudine (LAM) inhibited HBsAg and HBeAg expression by 83.6 and 85.4%, respectively. Further molecular docking analysis revealed formations of strong complexes of RPT, ECR and LAM with HBV polymerase through interactions with binding pocket residues. Taken together, the present results demonstrated promising therapeutic potential of the novel-derived catechin and epicatechin for HBV, warranting their further molecular and pharmacological evaluation.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiviral Agents : CK(1957) : AC(1034)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.