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Abstract Title:

COVID-19 reinfections among naturally infected and vaccinated individuals.

Abstract Source:

Sci Rep. 2022 01 26 ;12(1):1438. Epub 2022 Jan 26. PMID: 35082344

Abstract Author(s):

Sezanur Rahman, M Mahfuzur Rahman, Mojnu Miah, Mst Noorjahan Begum, Monira Sarmin, Mustafa Mahfuz, Mohammad Enayet Hossain, Mohammed Ziaur Rahman, Mohammod Jobayer Chisti, Tahmeed Ahmed, Shams El Arifeen, Mustafizur Rahman

Article Affiliation:

Sezanur Rahman

Abstract:

The protection against emerging SARS-CoV-2 variants by pre-existing antibodies elicited due to the current vaccination or natural infection is a global concern. We aimed to investigate the rate of SARS-CoV-2 infection and its clinical features among infection-naïve, infected, vaccinated, and post-infection-vaccinated individuals. A cohort was designed among icddr,b staff registered for COVID-19 testing by real-time reverse transcriptase-polymerase chain reaction (rRT-PCR). Reinfection cases were confirmed by whole-genome sequencing. From 19 March 2020 to31 March 2021, 1644 (mean age, 38.4 years and 57% male) participants were enrolled; where 1080 (65.7%) were tested negative and added to the negative cohort. The positive cohort included 750 positive patients (564 from baseline and 186 from negative cohort follow-up), of whom 27.6% were hospitalized and 2.5% died. Among hospitalized patients, 45.9% had severe to critical disease and 42.5% required oxygen support. Hypertension and diabetes mellitus were found significantly higher among the hospitalised patients compared to out-patients; risk ratio 1.3 and 1.6 respectively. The risk of infection among positive cohort was 80.2% lower than negative cohort (95% CI 72.6-85.7%; p < 0.001). Genome sequences showed that genetically distinct SARS-CoV-2 strains were responsible for reinfections. Naturally infected populations were less likely to be reinfected by SARS-CoV-2 than the infection-naïve and vaccinated individuals. Although, reinfected individuals did not suffer severe disease, a remarkable proportion of naturally infected or vaccinated individuals were (re)-infected by the emerging variants.

Study Type : Human Study

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