Article Publish Status: FREE
Abstract Title:

Juice (camu-camu) Exhibits Analgesic and Antiedematogenic Activities in Mice.

Abstract Source:

J Med Food. 2020 Dec 18. Epub 2020 Dec 18. PMID: 33337272

Abstract Author(s):

Francisco Carlos da Silva, Alessandra Hübner de Souza, Bruna Kempfer Bassoli, Gleiciane Alves Prates, Cíntia Daudt, Dionatas Ulises de Oliveira Meneguetti, Áurea Pandolfo Corrêa, Iasmine Berbigier de Oliveira, Sandro de Vargas Schons, Maria Fernanda Pessano Fialho, Dione Silva Correa, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz

Article Affiliation:

Francisco Carlos da Silva


The(Myrtaceae) fruit is traditionally used to treat malnutrition due to its high levels of vitamin C and phenolic compounds. Because of its composition, this plant is very promising in the research of novel natural treatment for pain disorders. This study analyzed the phytochemical profile ofjuice and assessed its antinociceptive and antiedematogenic potential. The phytochemical profile was determined through high-performance liquid chromatography (HPLC), the oral antinociceptive effect of50% juice (Md50) was evaluated by formalin, hot plate and Complete Freund's Adjuvant tests and the antiedematogenic activity by paw edema. HPLC revealed the presence of ascorbic acid, rutin, and ellagic acid as major compounds. Md50 showed an antinociceptive effect in the acute and chronic phases of the formalin test. In the hot plate test, Md50 also induced an antinociceptive effect of 0.5 up to 6 h, showing antinociceptive and antiedematogenic potential without changing the spontaneous locomotion of animals. All protocols were submitted and approved by the Ethics Committee for use of Animals of the Lutheran University of Brazil (protocol No. 2013-30P).

Study Type : Animal Study

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