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Article Publish Status: FREE
Abstract Title:

Mucoadhesive film containingα-mangostin shows potential role in oral cancer treatment.

Abstract Source:

BMC Oral Health. 2021 10 10 ;21(1):512. Epub 2021 Oct 10. PMID: 34629065

Abstract Author(s):

Piyawat Tangsuksan, Jureeporn Chuerduangphui, Chutha Takahashi Yupanqui, Teerapol Srichana, Ekarat Hitakomate, Chamsai Pientong, Tipaya Ekalaksananan, Wipawee Nittayananta

Article Affiliation:

Piyawat Tangsuksan

Abstract:

BACKGROUND: Oral cancer is often preceded by a mucosal lesion called an oral potentially malignant disorder (OPMD). Many plant-derived compounds are of value in medicine. The objectives of this study were to develop a soluble mucoadhesive film containingα-mangostin (α-MG), a compound extracted from the peel of mangosteen fruit, and determine its activities against oral cancer cells, against human papillomavirus type 16 (HPV-16) pseudovirus, and its anti-inflammatory properties.

METHODS: A soluble mucoadhesive film containingα-MG was prepared. Oral squamous carcinoma cell line (SCC25), murine macrophage cells (RAW264.7), and human gingival fibroblast cell line were cultured. Anticancer activity and viability of SCC25 cells in response to α-MG film solution were determined by MTT assay. HPV-16 pseudovirus was constructed and effects of the film solution on attachment and post-attachment steps of the infection were investigated. Anti-inflammatory activity was assessed by nitric oxide (NO) inhibition. Fibroblast cell migration was determined by in vitro scratch assay.

RESULTS: The solubleα-MG film showed cytotoxic effects on SCC25 cells in concentration> 125 µg/ml with ICof 152.5 µg/ml. Antiviral activity against HPV-16 pseudovirus was observed at attachment step, but not at post-attachment step. The film also possessed a strong anti-inflammatory effect and promoted wound healing without cytotoxicity.

CONCLUSIONS: Mucoadhesive film containingα-MG has a cytotoxic effect on oral squamous carcinoma cell line and an inhibitory effect on HPV-16 pseudovirus at attachment step. The α-MG film also shows a potent anti-inflammatory activity and enhances wound healing. Thus, the soluble α-MG film may have a potential role in treating oral cancer.

Study Type : In Vitro Study

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Sayer Ji
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