Abstract Title:

Analysis of rat testicular proteome following 30-day exposure to 900 MHz electromagnetic field radiation.

Abstract Source:

Electrophoresis. 2014 Dec ;35(23):3331-8. Epub 2014 Oct 18. PMID: 25146694

Abstract Author(s):

Masood Sepehrimanesh, Nasrin Kazemipour, Mehdi Saeb, Saeed Nazifi

Article Affiliation:

Masood Sepehrimanesh


The use of electromagnetic field (EMF) generating apparatuses such as cell phones is increasing, and has caused an interest in the investigations of its effects on human health. We analyzed proteome in preparations from the whole testis in adult male Sprague-Dawley rats that were exposed to 900 MHz EMF radiation for 1, 2, or 4 h/day for 30 consecutive days, simulating a range of possible human cell phone use. Subjects were sacrificed immediately after the end of the experiment and testes fractions were solubilized and separated via high-resolution 2D electrophoresis, and gel patterns were scanned, digitized, and processed. Thirteen proteins, which were found only in sham or in exposure groups, were identified by MALDI-TOF/TOF-MS. Among them, heat shock proteins, superoxide dismutase, peroxiredoxin-1, and other proteins related to misfolding of proteins and/or stress were identified. These results demonstrate significant effects of radio frequency modulated EMFs exposure on proteome, particularly in protein species in the rodent testis, and suggest that a 30-day exposure to EMF radiation induces nonthermal stress in testicular tissue. The functional implication of the identified proteins was discussed.

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