Abstract Title:

Low-dose oral ferrous fumarate aggravated intestinal inflammation in rats with DSS-induced colitis.

Abstract Source:

Inflamm Bowel Dis. 2005 Aug;11(8):744-8. PMID: 16043990

Abstract Author(s):

Kari Erichsen, Anne Marita Milde, Gülen Arslan, Lars Helgeland, Oddrun Anita Gudbrandsen, Rune J Ulvik, Rolf K Berge, Trygve Hausken, Arnold Berstad

Article Affiliation:

Department of Medicine, Haukeland University Hospital, Bergen, Norway. kari.erichsen@helse-bergen.no


BACKGROUND: Oral ferrous iron therapy may reinforce intestinal inflammation. One possible mechanism is by catalyzing the production of reactive oxygen species. We studied the effects of low-dose oral ferrous fumarate on intestinal inflammation and plasma redox status in dextran sulfate sodium (DSS)-induced colitis in rats. METHODS: Forty male Wistar rats were divided into 5 groups: no intervention, sham gavage (distilled water), ferrous fumarate, DSS, and ferrous fumarate + DSS. Ferrous fumarate was dissolved in distilled water (0.60 mg Fe/kg per day) and administered by gavage on days 1 to 14. All rats were fed a standard diet. Colitis was induced by 5% DSS in drinking water on days 8 to 14. Rats were killed on day 16. Histologic colitis scores, fecal granulocyte marker protein, plasma malondialdehyde, plasma antioxidant vitamins, and plasma aminothiols were measured. RESULTS: DSS significantly increased histologic colitis scores (P<0.001) and fecal granulocyte marker protein (P<0.01). Ferrous fumarate further increased histologic colitis scores (P<0.01) in DSS-induced colitis. DSS + ferrous fumarate decreased plasma vitamin A compared with controls (P<0.01). Otherwise, no changes were seen in plasma malondialdehyde, plasma antioxidant vitamins, or plasma aminothiols. CONCLUSION: Low-dose oral ferrous iron enhanced intestinal inflammation in DSS-induced colitis in rats.

Study Type : Animal Study
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