Abstract Title:

Longitudinal vitamin D deficiency is inversely related to mite sensitization in early childhood.

Abstract Source:

Pediatr Allergy Immunol. 2017 Dec 14. Epub 2017 Dec 14. PMID: 29240264

Abstract Author(s):

Chih-Yung Chiu, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Tsung-Chieh Yao, Kuo-Wei Yeh, Jing-Long Huang

Article Affiliation:

Chih-Yung Chiu


BACKGROUND: There are few studies addressing the longitudinal analysis of vitamin D deficiency and its impact to the development of atopic diseases in early childhood.

METHODS: We investigated 155 children who regularly followed up at our clinic for 5 years as subjects enrolled in a birth cohort study. The pattern of vitamin D levels from birth to 5 years of age was clustered using K-means method in R software. Absolute eosinophil count (AEC), total serum and specific immunoglobulin E antibodies against food (egg white, milk, and wheat) and inhalant allergens (D. pteronyssinus, D. farina, and C. herbarum) were measured at 1.5, 3, 4 and 5 years of age.

RESULTS: A total of 137 children with serum samples obtained over at least 3 time-points during the follow-up period were recruited. By using K-means clustering, the dynamic changes in vitamin D levels was significantly stratified into 3 clusters (cluster A,≥ 30 ng/mL, n = 61; cluster B, 20 - 29.9 ng/mL, n = 53; cluster C,<20 ng/mL, n = 23). Despite no statistical association with atopic diseases, a persistent vitamin D deficiency appeared to be associated with eosinophilia at age 3, and total serum and mite-specific IgE levels at age 4. At which age, a higher prevalence of mite sensitization was significantly associated with the risk of allergic rhinitis and asthma.

CONCLUSIONS: Vitamin D deficiency is inversely associated with AEC and mite-specific IgE levels, which may potentially increase susceptibility to develop allergies including rhinitis and asthma in early childhood. This article is protected by copyright. All rights reserved.

Study Type : Human Study

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