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Abstract Title:

Licochalcone A-loaded solid lipid nanoparticles improve antischistosomal activityand.

Abstract Source:

Nanomedicine (Lond). 2021 08 ;16(19):1641-1655. Epub 2021 Jul 14. PMID: 34256609

Abstract Author(s):

Lívia Mara Silva, Danielle Gomes Marconato, Marcos Paulo Nascimento da Silva, Nádia Rezende Barbosa Raposo, Gabriela de Faria Silva Facchini, Gilson Costa Macedo, Fernanda de Sá Teixeira, Maria Cecília Barbosa da Silveira Salvadori, Priscila de Faria Pinto, Josué de Moraes, Frederico Pittella, Ademar Alves Da Silva Filho

Article Affiliation:

Lívia Mara Silva

Abstract:

To isolate licochalcone A (LicoA) from licorice, prepare LicoA-loaded solid lipid nanoparticles (L-SLNs) and evaluate the L-SLNsandagainst.LicoA was obtained by chromatographic fractionation and encapsulated in SLNs by a modified high shear homogenization method.L-SLNs showed high encapsulation efficiency, with satisfactory particle size, polydispersity index and Zeta potential. Transmission electron microscopy revealed that L-SLNs were rounded and homogenously distributed. Toxicity studies revealed that SLNs decreased the hemolytic and cytotoxic properties of LicoA. Treatment with L-SLNs showedefficacy against.L-SLNs are efficient in reducing worm burden and SLNs may be a promising delivery system for LicoA to treatinfections.

Study Type : Animal Study

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