Abstract Title:

complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.

Abstract Source:

Scand J Gastroenterol. 2022 May 9:1-7. Epub 2022 May 9. PMID: 35534443

Abstract Author(s):

Xue Chen, Feng Gao, Jie Zhang

Article Affiliation:

Xue Chen


OBJECTIVES: Aspirin can reduce cardiovascular disease risk; however, it can increase the risk of gastrointestinal injury.have some protective effects; however, there are few studies on their effects on humans. This study investigates the effects ofcomplex capsule treatment on the aspirin-related small intestinal mucosal injury.

METHODS: This single-center, prospective, randomized controlled clinical trial included 69 patients using enteric-coated aspirin for>1 month between May and December 2019. After baseline magnetically controlled capsule endoscopy (MCCE), patients with aspirin-related small intestinal mucosal injury were randomly assigned (1:1) to receive enteric-coated aspirincomplex capsules containing a combination of,, and(probiotics group) or enteric-coated aspirin only (control group) for 2 months. After treatment, the patient underwent MCCE again. The primary outcome was the change in small intestinal mucosal injury scores from baseline to post-intervention.

RESULTS: Twenty-five patients in the probiotics group and 28 in the control group completed the trial. The decrease in small intestinal mucosal injury scores from baseline to post-intervention was significantly greater in the probiotics group than that in the control group ( < .001). The improvement rates of red spots and erosions in the probiotics group were higher compared with the control group ( = .027 and .022, respectively), and the improvement rate of small intestinal ulcers in the probiotics group was 75.0%; however, there was no improvement in the control group.

CONCLUSION: complex capsules can ameliorate aspirin-related small intestinal mucosal injury.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.