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Abstract Title:

complex capsules ameliorate aspirin-related small intestinal mucosal injury: a prospective, randomized, controlled clinical trial.

Abstract Source:

Scand J Gastroenterol. 2022 May 9:1-7. Epub 2022 May 9. PMID: 35534443

Abstract Author(s):

Xue Chen, Feng Gao, Jie Zhang

Article Affiliation:

Xue Chen

Abstract:

OBJECTIVES: Aspirin can reduce cardiovascular disease risk; however, it can increase the risk of gastrointestinal injury.have some protective effects; however, there are few studies on their effects on humans. This study investigates the effects ofcomplex capsule treatment on the aspirin-related small intestinal mucosal injury.

METHODS: This single-center, prospective, randomized controlled clinical trial included 69 patients using enteric-coated aspirin for>1 month between May and December 2019. After baseline magnetically controlled capsule endoscopy (MCCE), patients with aspirin-related small intestinal mucosal injury were randomly assigned (1:1) to receive enteric-coated aspirincomplex capsules containing a combination of,, and(probiotics group) or enteric-coated aspirin only (control group) for 2 months. After treatment, the patient underwent MCCE again. The primary outcome was the change in small intestinal mucosal injury scores from baseline to post-intervention.

RESULTS: Twenty-five patients in the probiotics group and 28 in the control group completed the trial. The decrease in small intestinal mucosal injury scores from baseline to post-intervention was significantly greater in the probiotics group than that in the control group ( < .001). The improvement rates of red spots and erosions in the probiotics group were higher compared with the control group ( = .027 and .022, respectively), and the improvement rate of small intestinal ulcers in the probiotics group was 75.0%; however, there was no improvement in the control group.

CONCLUSION: complex capsules can ameliorate aspirin-related small intestinal mucosal injury.

Study Type : Human Study

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Sayer Ji
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