Article Publish Status: FREE
Abstract Title:

versus triple therapy for the eradication ofin functional dyspepsia.

Abstract Source:

Med Pharm Rep. 2019 Oct ;92(4):352-355. Epub 2019 Oct 25. PMID: 31750434

Abstract Author(s):

Iulia Antonia Pop Muresan, Lucian Liviu Pop, Dan L Dumitrascu

Article Affiliation:

Iulia Antonia Pop Muresan


Background and aim: The eradication ofinfection using PPI associated with different combinations of two or three antibiotics entails high risks of side effects and non- adherence. Therefore probiotics have been proposed foreradication.We tested the efficacy ofplus Pantoprazole compared to a triple regimen based on Pantoprazole plus Amoxicillin plus Clarithromycin in patients withinfection and functional dyspepsia.

Methods: In a prospective design, 46 patients (M: 13, F: 33, mean age 48.80± 13.82 years) fulfilled the following inclusion criteria: age at least 18, documented informed consent, positivefinding by histology, no morphological changes of the gastric mucosa at upper gastrointestinal endoscopy and complaints of functional dyspepsia according to the Rome III criteria. Exclusion criteria were: presence of any other chronic organic diseases that required drug treatment, use of antibiotics, PPIs or H2 antagonists in the previous 3 months; pregnancy or lactation. Patients were randomly divided into two equal groups (23 patients each group). One group received the standard therapy in our area: Pantoprazole 40 mg bid for 30 days associated with Amoxicillin 2×1000 mg/day and Clarithromycin 500 mg bid for 14 days. The other group received Pantoprazole 40 mg/day plusDSMZ 17648 twice a day for 8 weeks. Post-treatment eradication was tested byantigen stool assay at 30 days after therapy.

Results: The group onplus Pantoprazole presented 65.22% eradication rate compared to 73.91% cure rate in the group that received the Pantoprazole and Amoxicillin and Clarithromycin therapy, with no statistically significant difference in eradication rate between the two groups (p=0.75). The total adherence was good and eradication ofwas associated with improvement of dyspeptic symptoms for both eradication regimens.

Conclusion: is a good alternative for patients with chronic dyspepsia for the eradication ofinfection. Its efficacy is similar to the triple therapy.

Study Type : Human Study

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Sayer Ji
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