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Abstract Title:

Induction of apoptosis in murine leukemia by diarylheptanoids from Curcuma comosa Roxb.

Abstract Source:

Cell Biol Toxicol. 2011 Dec ;27(6):413-23. Epub 2011 Jul 16. PMID: 21766178

Abstract Author(s):

Surawat Jariyawat, Thanapol Thammapratip, Kanoknetr Suksen, Podchanart Wanitchakool, Jintapat Nateewattana, Arthit Chairoungdua, Apichart Suksamrarn, Pawinee Piyachaturawat

Article Affiliation:

Surawat Jariyawat

Abstract:

Diarylheptanoids, isolated from the rhizome of Curcuma comosa Roxb., have several biological activities including anti-oxidant and anti-inflammation. The present study investigated the effect of five diarylheptanoids isolated from C. comosa rhizome on the proliferation of murine P388 leukemic cells. Compound-092, (3S)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-ol, bearing a catechol moiety, was the most potent diarylheptanoid (IC(50) of 4 μM) in inhibiting P388 leukemic cell viability by causing DNA breakage and inducing apoptosis. Apoptotic cell death was characterized by the presence of chromatin condensation, formation of apoptotic bodies, DNA fragmentation, and externalization of plasma membrane phosphatidylserine. This compound increased caspase-3 activity about fivefold above the untreated control, decreased the intracellular reduced glutathione level, and impaired mitochondrial transmembrane potential. In the presence of Cu(II) ion, the compound exhibited a pro-oxidant activity causing DNA strand breakage and enhancing the anti-proliferative activity. The results provide evidence for the pro-oxidant activity of the diarylheptanoid bearing a catechol moiety in the induction of apoptosis in murine P388 leukemia.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(6986) : AC(5304)

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