Article Publish Status: FREE
Abstract Title:

Improvement Effect of Sweet Basil (Ocimum basilicum L.) Powder Intake on Obese Mice Fed a High-fat and High-sucrose Diet.

Abstract Source:

J Oleo Sci. 2021 Aug 6. Epub 2021 Aug 6. PMID: 34373411

Abstract Author(s):

Chikako Kiyose, Haruka Takeuchi, Yoshimni Yabe, Tomoya Koike, Kazutaka Sakiya, Mana Nagase, Rieko Tanaka-Yachi, Chie Takahashi-Muto

Article Affiliation:

Chikako Kiyose


This study aimed to determine if there are anti-inflammatory and anti-obesity effects of sweet basil, an herb, in mice. Sweet basil was administered as a powder to male C57BL/6JJcl mice, which were divided into three groups: the (control [C], high-fat and high-sucrose diet [H], and high-fat and high-sucrose diet plus sweet basil powder [HB]) groups. The mice were fed for 12 weeks and the dry sweet basil powder comprised 1% per kg of the diet. From experiment third week, the average body weight was significantly higher in the H group than in the C group. The average body weight was significantly lower in the HB group than in the H group, but food intake did not significantly differ between the H and HB groups. Liver weight was drastically lower in the HB group than in the H group. Perirenal fat weight and epididymal fat weight were not significantly different between the H and HB groups. Therefore, we assumed that body-weight reduction caused by sweet basil powder intake depended on inhibition of liver enlargement. We then examined lipid metabolism-related gene expression in the mice livers. Expression of the sterol response element binding protein 1-c gene tended to be lower in the HB group than in the H group (p=0.056). We speculated that sweet basil inhibited liver enlargement by suppressing fatty acid synthesis. Moreover, expression of the monocyte chemoattractant protein-1 gene in epididymal fat was significantly lower in the HB group than in the H group. Sweet basil powder appears to have a potent anti-inflammatory effect in the adipose tissue of mice fed a high-fat and high-sucrose diet.

Study Type : Animal Study

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