n/a
Article Publish Status: FREE
Abstract Title:

Impact of Berberine on Some Epigenetic, Transcription Regulation and Inflammatory Biomarkers in a Mice Model of Epilepsy.

Abstract Source:

Rep Biochem Mol Biol. 2021 Oct ;10(3):362-372. PMID: 34981012

Abstract Author(s):

Heba Bassiony Ghanem, Marwa Nagy Emam, Ali Dareen Abdelaziz Mohammed, Abd-Ellatif Rania Nagi

Article Affiliation:

Heba Bassiony Ghanem

Abstract:

Background: Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on some epigenetic, transcription regulation&inflammatory biomarkers in a mice model of epilepsy.

Methods: This work was performed on; Group I: (control), Group II: berberine-treated control,Group III: epilepsy group, Group IV: berberine-treated epilepsy. Groups were subjected to assessment of Tumor growth factor-1β (TGF-1β), hypoxia inducible factor-1α (HIF-1α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity&neuronal restrictive silencing factor (NRSF) gene expression.

Results: Study showed significant increase in levels of HIF-1α, TGF-1β, HDAC activity&NRSF gene expression in epilepsy group&decrease in these levels in berberine treated epilepsy group. Significant decrease in BDNF levels in epilepsy&elevation in them in berberine treated epilepsy group.

Conclusion: Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors&inflammatory biomarkers in a mice model of epilepsy.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.