Article Publish Status: FREE
Abstract Title:

Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence.

Abstract Source:

Mol Cells. 2011 May ;31(5):423-9. Epub 2011 Feb 22. PMID: 21359681

Abstract Author(s):

Jong Seok Yun, Jung Woon Pahk, Jong Seok Lee, Won Cheol Shin, Shin Young Lee, Eock Kee Hong

Article Affiliation:

Jong Seok Yun


In this study, we investigated the cytoprotective effects of Inonotus obliquus against oxidative stress-induced apoptosis and premature senescence. Pretreatment with I. obliquus scavenged intracellular ROS and prevented lipid peroxidation in hydrogen peroxide-treated human fibroblasts. As a result, I. obliquus exerted protective effects against hydrogen peroxide-induced apoptosis and premature senescence in human fibroblasts. In addition, I. obliquus suppressed UV-induced morphologic skin changes, such as skin thickening and wrinkle formation, in hairless mice in vivo and increased collagen synthesis through inhibition of MMP-1 and MMP-9 activities in hydrogen peroxide-treated human fibroblasts. Taken together, these results demonstrate that I. obliquus can prevent the aging process by attenuating oxidative stress in a model of stress-induced premature senescence.

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