Abstract Title:

Hypoglycaemic seizure and neonatal acute adrenal insufficiency after maternal exposure to prednisone during pregnancy: a case report.

Abstract Source:

Eur J Pediatr. 2010 Jun;169(6):763-5. Epub 2009 Nov 10. PMID: 19902248

Abstract Author(s):

Pierre-Jean Saulnier, Xavier Piguel, Marie Christine Perault-Pochat, Cassandra Csizmadia-Bremaud, Jean-Pascal Saulnier

Article Affiliation:

Department of Clinical Pharmacology and Regional Center of Pharmacovigilance, CHU de Poitiers, Poitiers, France. p.j.saulnier@chu-poitiers.fr


Neonatal acute adrenal insufficiency (AAI) is a rare but severe condition. We report a case of AAI following maternal exposure to moderate doses of corticosteroids during pregnancy. The neonate, born at term, presented with hypoglycaemia complicated by seizures. The AAI was confirmed by endocrine tests and after exclusion of differential diagnoses. Early diagnosis and treatment led to full recovery.

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