Article Publish Status: FREE
Abstract Title:

Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study).

Abstract Source:

Eur J Nutr. 2020 Jul 13. Epub 2020 Jul 13. PMID: 32661681

Abstract Author(s):

Rosa M Valls, Anna Pedret, Lorena Calderón-Pérez, Elisabet Llauradó, Laura Pla-Pagà, Judit Companys, Ana Moragas, Francisco Martín-Luján, Yolanda Ortega, Montse Giralt, Marta Romeu, Laura Rubió, Jordi Mayneris-Perxachs, Núria Canela, Francesc Puiggrós, Antoni Caimari, Josep M Del Bas, Lluís Arola, Rosa Solà

Article Affiliation:

Rosa M Valls


PURPOSE: To assess the sustained and acute effects, as well as the influence of sustained consumption on the acute effects, of orange juice (OJ) with a natural hesperidin content and hesperidin-enriched OJ (EOJ) on blood (BP) and pulse (PP) pressures in pre- and stage-1 hypertensive individuals.

METHODS: In a randomized, parallel, double-blind, placebo-controlled trial, participants (n = 159) received 500 mL/day of control drink, OJ, or EOJ for 12 weeks. Two dose-response studies were performed at baseline and after 12 weeks.

RESULTS: A single EOJ dose (500 mL) reduced systolic BP (SBP) and PP, with greater changes after sustained treatment where a decrease in diastolic BP (DBP) also occurred (P < 0.05). SBP and PP decreased in a dose-dependent manner relative to the hesperidin content of the beverages throughout the 12 weeks (P < 0.05). OJ and EOJ decreased homocysteine levels at 12 weeks versus the control drink (P < 0.05). After 12 weeks of EOJ consumption, four genes related to hypertension (PTX3, NLRP3, NPSR1 and NAMPT) were differentially expressed in peripheral blood mononuclear cells (P < 0.05).

CONCLUSION: Hesperidin in OJ reduces SBP and PP after sustained consumption, and after a single dose, the chronic consumption of EOJ enhances its postprandial effect. Decreases in systemic and transcriptomic biomarkers were concomitant with BP and PP changes. EOJ could be a useful co-adjuvant tool for BP and PP management in pre- and stage-1 hypertensive individuals.

Study Type : Human Study

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Sayer Ji
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