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Article Publish Status: FREE
Abstract Title:

Hepatoprotective Effects of Different Extracts FromAgainst CCl-Induced Acute Liver Injury in Mice.

Abstract Source:

Front Pharmacol. 2021 ;12:664607. Epub 2021 Jul 5. PMID: 34290606

Abstract Author(s):

Xichuan Wei, Chuanhong Luo, Yanan He, Haozhou Huang, Fei Ran, Wei Liao, Peng Tan, Sanhu Fan, Yuan Cheng, Dingkun Zhang, Junzhi Lin, Li Han

Article Affiliation:

Xichuan Wei

Abstract:

is a traditional polyherbal formula used in Indian Ayurvedic and Chinese Tibetan medicine. A wide range of biological activities have been attributed to, but the impact of various extraction methods on efficacy has not been determined.The study aimed to evaluateextracts obtained by various methods for their hepatoprotective effects and molecular mechanisms in a mouse model of carbon tetrachloride (CCl)-induced liver injury.HPLC fingerprinting was used to characterize the chemical characteristics ofextracts obtained by (a) 0.5 h ultrasonication, (b) 2 h reflux, and (c) 4 h reflux. Hepatoprotective efficacy was evaluated in a mouse model of CCl-induced liver damage. Serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) were measured, as well as the liver antioxidant and inflammatory markers malondialdehyde superoxide dismutase glutathione peroxidase (GSH-Px), TNF-α, and IL-6. Gene and protein expression of Nrf-2 signaling components Nrf-2, heme oxygenase (HO-1), and NADPH Quinone oxidoreductase (NQO-1) in liver tissue were evaluated by real-time PCR and western blotting.Chemical analysis showed a clear difference in content between extracts produced by ultrasonic and reflux methods. The pharmacological analysis showed that all three Triphala extracts reduced ALT, AST, MDA, TNF-α, and IL-6 levels and increased SOD and GSH-Px. Triphala extracts also induced transcript and protein expression of Nrf-2, HO-1, and NQO-1.Triphala extract prevents CCl-induced acute liver injury. The ultrasonic extract of Triphala was most effective, suggesting that hepatoprotection may be related to the larger tannins via activation of Nrf-2 signaling.

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