Article Publish Status: FREE
Abstract Title:

Heat stability of the in vitro inhibitory effect of spices on lipase, amylase, and glucosidase enzymes.

Abstract Source:

Food Sci Nutr. 2019 Feb ;7(2):425-432. Epub 2019 Jan 28. PMID: 30847119

Abstract Author(s):

Irushika T Fernando, Kumudu I Perera, Senarath B P Athauda, Ramiah Sivakanesan, Nimal Savitri Kumar, Lalith Jayasinghe

Article Affiliation:

Irushika T Fernando


This study investigated the effect of boiling on the inhibitory action of spices on digestive enzymes. Unboiled extracts of(seed) (25.42%),(seed) (22.70%), and(seed) (19.17%) showed significantly (<0.05) a higher lipase inhibitory activity than their respective boiled extracts (20.23%, 15.74%, and 12.57%). Unboiled extracts of(stem bark) (-16.98%) and(seed) (-16.05%) showed an activation of lipase enzyme, and boiling significantly (<0.05) changed the activity into lipase inhibition as 8.47% and 9.54%, respectively. Unboiled extracts of(seed), and(seed) showed an activation of amylase enzyme, and boiling these extracts significantly reduced the enzyme activation. The other unboiled extracts showed a higher amylase inhibition than the boiled extracts, whereas the boiled extracts of(rhizome) and(flower) exhibited significantly (<0.05) lower values. Unboiled extracts of,, andshowed an insignificantly higher glucosidase inhibitory activity than the boiled extracts. Inhibition of digestive enzymes by nutritional intervention is one avenue to be considered in treating diet-induced obesity and in the management of postprandial hyperglycemia. Spices, used as food additives, could be a potential source of digestive enzyme inhibitors. The current study revealed that unboiled extracts of(seed),(seed), and(seed) are more effective than the boiled extracts as an antiobesity therapy. Moreover, it endorses the use of infusion ofseeds as an antiobesity therapy.

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