Abstract Title:

The effect of warmth or/and vitamin E supplementation on forearm blood flow and forearm vascular resistance in sickle cell and non sickle cell anaemia subjects.

Abstract Source:

Niger Postgrad Med J. 2003 Mar ;10(1):6-12. PMID: 12717457

Abstract Author(s):

S I Jaja, T A Gbadamosi, M O Kehinde, S Gbenebitse

Article Affiliation:

Department of Physiology, College of Medicine, University of Lagos, P. M. B. 12003 Lagos, Nigeria.


The effects of warmth stimulation and/or supplementation with vitamin E (300 mg/day for 6 weeks) on forearm blood flow (FBF) and forearm vascular resistance (FVR) were measured in 8 sickle cell anaemia (SCA) (mean age = 22.8 + 0.8 years) and 11 non sickle cell anaemia (NSCA) subjects (mean age = 23.2 + 1.1 years) of both sexes. Warmth stimulation was induced by immersing the left foot in warm water at 400C for 2 minutes. Forearm blood flow was measured with the venous occlusion plethysmography method. Warmth increased FBF (p<0.01 in each group) and reduced FVR (p<0.05) in NSCA subjects. The change in FBF was greater (p<0.05) in the NSCA subjects than in the SCA subjects. Supplementation with vitamin E reduced systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) (p<0.001 in each case) in the NSCA subjects but had little or no effect on the SCA subjects. Vitamin E increased FBF in NSCA subjects (p<0.05) and SCA subjects (p<0.01) and decreased FVR in both groups (p<0.05 in NSCA and p<0.01 in SCA subjects). The change in FVR seen in the NSCA subjects was less (p<0.01) than the change in SCA subjects. After supplementation with vitamin E, warmth further decreased SBP (p<0.01 in each group) and FVR (p<0.01 in each case) and increased FBF in both groups (p<0.01 respectively). The changes caused by warmth after vitamin E supplementation on the blood pressure parameters, FBF and FVR were similar in the two groups of subjects.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.