Abstract Title:

Halimane and labdane diterpenoids from Leonurus japonicus and their anti-inflammatory activity.

Abstract Source:

Phytochemistry. 2020 Apr ;172:112280. Epub 2020 Feb 7. PMID: 32036185

Abstract Author(s):

Hang-Ying Li, Ya Li, Wen-Jun Wei, Kai-Liang Ma, Jian-Jun Chen, Kun Gao

Article Affiliation:

Hang-Ying Li


Ten highly oxygenated diterpenoids (nine undescribed ones) were isolated from the aerial parts of Leonurus japonicus Houtt. 14,15-Dinor-labd-5,8-dien-3,13-dione was a 14,15-dinor-labdane diterpenoid possessing a Cskeleton. 7β,9α-Dihydroxy-6-oxo-labd-13-en-15,16-amide represented a rare example of labdane diterpenoid featuring an α,β-unsaturated-γ-lactam moiety. The structures of all compounds were elucidated using spectroscopic data analyses and comparisons. The effects of these obtained compounds on nitric oxide(NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cells were evaluated.(10R*,13R*,15R*)-15,16-Epoxy-6,13-dihydroxy-15-methoxy-labda-5,8-dien-7-one inhibited NO production with an ICvalue of 40.1 μM.

Study Type : In Vitro Study

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