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Abstract Title:

Glucopyranose fromprevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota.

Abstract Source:

Food Funct. 2022 Jan 20. Epub 2022 Jan 20. PMID: 35048917

Abstract Author(s):

Xinling Song, Weijun Cui, Fanyun Meng, Qun Xia, Xueping Li, Minjie Hou, Le Jia, Jianjun Zhang

Article Affiliation:

Xinling Song

Abstract:

This study investigated the effects of PGPs (polysaccharides), a glucopyranose isolated from the mycelium ofand characterized with the main chain of→4)-α-D-Glcp-(1→, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application ofas prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD. The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-κB signalling pathways. Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance ofshort-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.

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