Article Publish Status: FREE
Abstract Title:

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy.

Abstract Source:

Sci Rep. 2021 Jan 8 ;11(1):44. Epub 2021 Jan 8. PMID: 33420094

Abstract Author(s):

Renata Mancini Banin, Meira Maria Forcelini Machado, Iracema Senna de Andrade, Lorenza Oliveira Testa Carvalho, Bruna Kelly Sousa Hirata, Heider Mendonça de Andrade, Viviane da Silva Júlio, Jéssica de Souza Figueiredo Borges Ribeiro, Suzete Maria Cerutti, Lila Missae Oyama, Eliane Beraldi Ribeiro, Mônica Marques Telles

Article Affiliation:

Renata Mancini Banin


While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, andincreased the anxiety index (p = 0.048 vs. Sham + GbE) while it decreased the latency to immobility (p = 0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p = 0.004) and increased thelatency to immobility (p = 0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p = 0.047) and total cholesterol levels (p = 0.022) were associated with anxious-like behaviours while body adiposity (p = 0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause.

Study Type : Animal Study

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