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Article Publish Status: FREE
Abstract Title:

Influence of ethanolic extract ofongene and its anticancer potential in N-Nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in male albino rats.

Abstract Source:

Iran J Basic Med Sci. 2022 Apr ;25(4):497-505. PMID: 35656070

Abstract Author(s):

Godwin Offumobi Ogar, Joseph Bamidele Minari, Adebayo Joseph Bello, Janet Chiwetalu, Oluwafunto Eunice Omogunwa, Oluwadamilola Suzan Oshikoya, Micheal Tobiloba Otaru, Chioma Anastacia Anyanele

Article Affiliation:

Godwin Offumobi Ogar

Abstract:

Objectives: Cancer is a group of genetic disorders in which the behavior of the cell is disturbed by mutation and other abnormalities thereby posing as the leading cause of morbidity and mortality globally. Hepatocellular Carcinoma (HCC) is the most common form of liver cancer, highly aggressive with high mortality and incidence rate; and has limited therapeutic options. Most of the conventional cancer chemotherapeutics are associated with undesirable side effects, toxicity, chemoresistance, and high treatment cost, driving the need for a safer and more effective treatment alternative. Medicinal plants and herbs have shown very promising anti-cancer properties which are important for cancer treatment due to their multiple chemical compounds.

Materials and Methods: Qualitative screening of the ethanolic extractofwas conducted showing the different phytochemicalspresent. The levels of liver function and hematological parameters wasdetermined via spectrophotometric analysis. Polymerase Chain Reaction techniquewas used to assess the gene patterns of Tumorsuppressor p53 (TP53).

Results: Phytochemical analysis revealed thathas properties that antagonize the proliferating process of carcinogenesis in the liver. The NDEA-group showed significant distortion in the liver architecture characterized by vascular congestion of blood sinusoids, cirrhosis, and congestive hepatopathy while the treated groups showed a reduction in the abnormalities and malignant formation. The treated group showed a significant (<0.05) increase and restored activities of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Bilirubin and hematological parameters (RBCs, WBCs, and Platelets).gene amplification was significantly (<0.05) visible after treatment.

Conclusion: Ethanolic plant extract ofdemonstrates its anticancer properties by improving the liver architecture, increasing the antioxidant defense systems, and activation of the tumor suppressor () gene. Garlic extract has anti-proliferating properties and can be used as an alternative mode of treatment and prevention for hepatocellular carcinoma.

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Sayer Ji
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