Abstract Title:

Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana.

Abstract Source:

J Asian Nat Prod Res. 2018 Jan 7:1-7. Epub 2018 Jan 7. PMID: 29307236

Abstract Author(s):

Sabrin Ragab Mohamed Ibrahim, Gamal Abdallah Mohamed, Mahmoud Abdelkhalek Elfaky, Rwaida Adel Al Haidari, Mohamed Fathalla Zayed, Amal Abd-Elmoneim El-Kholy, Amgad Ibrahim Mansour Khedr

Article Affiliation:

Sabrin Ragab Mohamed Ibrahim


A new prenylated xanthone, garcixanthone A (5), together with eight known compounds, mangostanaxanthones I (1) and II (2), garcinone E (3),β-mangostin (4), 8-hydroxycudraxanthone G (6), garcinone C (7), cudraxanthone G (8), and (-)-epicatechin (9) were isolated from the EtOAc-soluble fraction of the air-dried pericarps of Garcinia mangostana (family Clusiaceae). Their structures were verified on the basis of spectroscopic data interpretation as well as comparison with the literature. The cytotoxic and antimicrobial activities of the new compound were assessed using sulforhodamine B (SRB) and agar disk diffusion assays, respectively. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma (A549) and breast carcinoma (MCF7) cell lines with IC50s 3.0 and 4.2 μM, respectively, compared to doxorubicin (0.74 and 0.41 μM, respectively).

Study Type : In Vitro Study

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