Article Publish Status: FREE
Abstract Title:

Epigenetic Factors in Late-Onset Alzheimer's Disease:andGene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins.

Abstract Source:

Int J Mol Sci. 2019 Jan 14 ;20(2). Epub 2019 Jan 14. PMID: 30646578

Abstract Author(s):

Gustavo C Román, Oscar Mancera-Páez, Camilo Bernal

Article Affiliation:

Gustavo C Román


DNA methylation and other epigenetic factors are important in the pathogenesis of late-onset Alzheimer's disease (LOAD). Methylenetetrahydrofolate reductase () gene mutations occur in most elderly patients with memory loss. MTHFR is critical for production of S-adenosyl-l-methionine (SAM), the principal methyl donor. A common mutation (1364T/T) of the cystathionine-γ-lyase () gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD. Other causes of hyperhomocysteinemia include aging, nutritional factors, and deficiencies of B vitamins. We emphasize the importance of supplementing vitamin B(methylcobalamin), vitamin B₉ (folic acid), vitamin B₆ (pyridoxine), and SAM to patients in early stages of LOAD.

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