Abstract Title:

Effects of eicosapentaenoic acids on oxidative stress and plasma fatty acid composition in patients with lupus nephritis.

Abstract Source:

Int J Obes (Lond). 2006 Aug;30(8):1298-307. Epub 2006 Feb 14. PMID: 16097442

Abstract Author(s):

Norio Nakamura, Ryuichiro Kumasaka, Hiroshi Osawa, Hideaki Yamabe, Ken-Ichi Shirato, Takeshi Fujita, Rei-Ichi Murakami, Michiko Shimada, Masayuki Nakamura, Ken Okumura, Kei Hamazaki, Tomohito Hamazaki


Eicosapentaenoic acid (EPA) is one of the major components of fish oil, which was reported to have antiatherogenic, anti-inflammatory and immune suppressive effects. In the present study, highly purified EPA was administered to patients with lupus nephritis and the effects of EPA on urinary 8-isoprostane, a reliable marker of oxidative stress, were investigated in these patients. Six outpatients (1 man and 5 women), with lupus nephritis diagnosed by renal biopsy, were entered in the study. We administered 1800 mg EPA ethyl-ester (purity > 95%) daily and examined the urinary 8-isoprostane levels and plasma fatty acid composition before and 3 months after EPA treatment. The urinary 8-isoprostane levels were significantly decreased after the treatment compared with those before the treatment (from 530 +/- 113 pg/mg x Cr to 235 +/- 49 pg/mg x Cr, p = 0.02). The EPA levels in the plasma phospholipid (PL) fraction were significantly increased after the treatment (from 3.30 +/- 0.64 mol% to 8.01 +/- 0.47 mol%, p < 0.001). Arachidonic acid (AA) levels in the plasma PL fraction were significantly decreased after the treatment (from 9.47 +/- 0.28 mol% to 7.33 +/- 0.43 mol%, p < 0.001). The ratios of EPA to AA were significantly increased after the treatment (from 0.35 +/- 0.07 to 1.14 +/- 0.16, p < 0.001). Thus, this preliminary study indicated that EPA might exert beneficial effects on lupus nephritis by decreasing the oxidative stress.

Study Type : Human Study

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