Article Publish Status: FREE
Abstract Title:

Efficacy of Ethyl Acetate Fraction offor Cancer-Related Fatigue in Blood Biochemical andH-Nuclear Magnetic Resonance Metabolomic Analyses.

Abstract Source:

Integr Cancer Ther. 2020 Jan-Dec;19:1534735420932635. PMID: 32571104

Abstract Author(s):

Junsang Oh, Eunhyun Choi, Jayoung Kim, Heesu Kim, Sangheun Lee, Gi-Ho Sung

Article Affiliation:

Junsang Oh


This study investigated the adjuvant effects for anticancer and antifatigue of the combination ofextract with sorafenib. The 5 extracts ofwere obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. Among these extracts, ethyl acetate extract ofshowed the best tumor growth inhibitory activity and the adjuvant effects in combination with sorafenib. As a result of biochemical analysis with serum, the combination of ethyl acetate extract ofwith sorafenib showed the adjuvant effects both improving hepatic function and relieving cancer-related fatigue. In addition,H-nuclear magnetic resonance-based metabolic profiling in liver tissues showed that the change of metabolism by ethyl acetate extract ofwith sorafenib was related with serum fatigue biomarkers. Therefore, the combination strategy such as ethyl acetate extraction ofwith sorafenib constitutes a promising therapeutic strategy in hepatocellular carcinoma, via the inhibition of cancer growth, the enhancement of liver function, as well as the alleviation of cancer-related fatigue.

Study Type : In Vitro Study

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Sayer Ji
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