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Abstract Title:

Echinacoside protects adenine-induced uremic rats from sciatic nerve damage by up-regulatingα-Klotho.

Abstract Source:

J Musculoskelet Neuronal Interact. 2021 09 1 ;21(3):413-421. PMID: 34465681

Abstract Author(s):

Yingdan Zhao, Yang Yi, Bo Gu, Hanqing Wang, Jun Ma, Zhiyong Guo

Article Affiliation:

Yingdan Zhao

Abstract:

OBJECTIVES: To investigate the therapeutic effect of Echinacoside on uremia-induced sciatic nerve injury and explore the specific molecular mechanism and role ofα-Klotho.

METHODS: SD rats were given continuous gavage of adenine to prepare a uremia-induced sciatic nerve injury model. The model was given either Echinacoside orα-Klotho by gavage. Histopathological changes of kidney and sciatic nerve were detected by H&E staining. The changes of creatinine, urea nitrogen, and urine protein were detected by biochemical detection. The changes of IL-1β and IL-18 were detected by ELISA. Nerve activity-related indicators were detected by biochemical detection. Changes in related mRNA and protein expression were detected by qPCR and western blot.

RESULTS: Creatinine, urea nitrogen, urine protein, and malondialdehyde (MDA) in the model group were significantly increased and inhibited by Echinacoside andα-Klotho treatment with Echinacoside dose-dependence. Meanwhile, the activities of ATP concentration, potassium adenosine triphosphate (Na+, K+ ATPase), succinate dehydrogenase (SDH), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) showed opposite trends.

CONCLUSIONS: Echinacoside can significantly relieve uremia-induced sciatic nerve injury in rats. Its specific molecular mechanism is related to the inhibition of the classical cellular pyroptosis pathway, which is likely achieved by promotingα-Klotho expression.

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Sayer Ji
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