Abstract Title:

Diterpenoids isolated from the root of Salvia miltiorrhiza and their anti-inflammatory activity.

Abstract Source:

Nat Prod Res. 2019 Apr 9:1-7. Epub 2019 Apr 9. PMID: 30961363

Abstract Author(s):

Thi Men Ngo, Phuong Thao Tran, Le Son Hoang, Jeong-Hyung Lee, Byung Sun Min, Jeong Ah Kim

Article Affiliation:

Thi Men Ngo


Four new diterpene-type compounds normiltirone (3) and isosalviamides F-H (14-16) together with twelve known compounds (1, 2, 4-13) were isolated from the roots of Salvia miltiorrhiza. Their structures were mainly elucidated from detailed spectroscopic data. All isolated compounds were evaluated for their ability to inhibit lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages. Compound 11 showed a strong inhibitory effect, with an ICvalue of 3.4 ± 1.2 μM.

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