Abstract Title:

Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia.

Abstract Source:

Gynecol Oncol. 2010 Sep;118(3):289-94. Epub 2010 Jun 18. PMID: 20691333

Abstract Author(s):

Erin M Siegel, Jason L Salemi, Luisa L Villa, Alex Ferenczy, Eduardo L Franco, Anna R Giuliano

Article Affiliation:

Risk Assessment, Detection and Intervention Program, Moffitt Cancer Center, Tampa, FL 33612, USA.


OBJECTIVE: Women with human papillomavirus (HPV) infections are at risk for developing squamous intraepithelial lesions (SIL) of the cervix; however, other factors are required for infections to progress to SIL. We hypothesize that consumption of fruits and vegetables high in antioxidant nutrients may prevent, in part, the development of HPV-associated SIL.

METHODS: This study is a nested case-control study of 265 HPV-positive women (93 SIL cases and 172 cytologically normal controls) in the Ludwig-McGill Cohort Study, São Paulo, Brazil. Diet was assessed by a self-administered food frequency questionnaire. The association between food and nutrient intake of antioxidants and incident SIL was determined by logistic regression and multinomial regression when comparing LSIL and HSILs.

RESULTS: Higher reported consumption of papaya was inversely associated with risk of SIL (p trend=0.01) and strongest for>or=1 time/week (adjusted odds ratios (AORs)=0.19; 95%CI, 0.08-0.49). Risk of SIL was reduced among women reporting consumption of oranges>or=1 time/week (AOR=0.32; 95%CI, 0.12-0.87; p-trend=0.02). Nutrient intakes of ss-cryptoxanthin and alpha-carotene were marginally protective against SIL.

CONCLUSIONS: Frequent consumption of fruits high in antioxidant nutrients appears to be associated with reduced risk of incident SIL among Brazilian women.

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.