Article Publish Status: FREE
Abstract Title:

The Demethoxy Derivatives of Curcumin Exhibit Greater Differentiation Suppression in 3T3-L1 Adipocytes Than Curcumin: A Mechanistic Study of Adipogenesis and Molecular Docking.

Abstract Source:

Biomolecules. 2021 Jul 14 ;11(7). Epub 2021 Jul 14. PMID: 34356649

Abstract Author(s):

Ahmed Alalaiwe, Jia-You Fang, Hsien-Ju Lee, Chun-Hui Chiu, Ching-Yun Hsu

Article Affiliation:

Ahmed Alalaiwe


Curcumin is a known anti-adipogenic agent for alleviating obesity and related disorders. Comprehensive comparisons of the anti-adipogenic activity of curcumin with other curcuminoids is minimal. This study compared adipogenesis inhibition with curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC), and their underlying mechanisms. We differentiated 3T3-L1 cells in the presence of curcuminoids, to determine lipid accumulation and triglyceride (TG) production. The expression of adipogenic transcription factors and lipogenic proteins was analyzed by Western blot. A significant reduction in Oil red O (ORO) staining was observed in the cells treated with curcuminoids at 20μM. Inhibition was increased in the order of curcumin

Study Type : In Vitro Study

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