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Article Publish Status: FREE
Abstract Title:

Delving into the Therapeutic Potential ofLeaf against Thrombocytopenia.

Abstract Source:

Molecules. 2022 Apr 25 ;27(9). Epub 2022 Apr 25. PMID: 35566112

Abstract Author(s):

Seemal Munir, Zhi-Wei Liu, Tayyaba Tariq, Roshina Rabail, Przemysław Łukasz Kowalczewski, Jacek Lewandowicz, Andrzej Blecharczyk, Muhammad Abid, Muhammad Inam-Ur-Raheem, Rana Muhammad Aadil

Article Affiliation:

Seemal Munir

Abstract:

Thrombocytopenia is a clinical manifestation that refers to the low platelet count, i.e.,<150× 10/μL, of blood, resulting in imbalanced hemostasis, which leads to several fatal complications. The causative factors vary greatly, but, as a consequence, they interfere with platelet production and promote destruction, leading to death.leaf has unique therapeutic and medicinal characteristics against thrombocytopenia, and this is supported by scientific studies. Secondary metabolites and minerals in the leaf, such as carpaine and quercetin, promote platelet production, inhibit platelet destruction, and maintain platelet membrane through gene expression activity and the ceasing of viral proteases, respectively. This review explores the scientific studies that support the role of papaya leaf in the form of juice, extract, or powder against thrombocytopenia through animal modeling and clinical trials. Phytochemical profiles ofleaf revealed the presence of flavonoids, alkaloids, phenols, cardiac glycosides, tannins, terpenes, and saponins, which impart therapeutic potential to the leaf. The therapeutic benefits of the leaf include immunomodulatory, antiviral, antidiabetic, anticancer, antimalarial, antiangiogenic, antibacterial, and antioxidant activities. Several conducted scientific research studies have proved the efficacy ofleaf against thrombocytopenia, expanding the implication of natural sources to eradicate numerous ailments.

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