Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells. - GreenMedInfo Summary

n/a

Abstract Title:

Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.

Abstract Source:

Phytochemistry. 2018 Jan ;145:10-17. Epub 2017 Oct 14. PMID: 29035776

Abstract Author(s):

Xin-Yi Liu, Shan Wang, Chuang-Jun Li, Jie Ma, Fang-You Chen, Ying Peng, Xiao-Liang Wang, Dong-Ming Zhang

Article Affiliation:

Xin-Yi Liu

Abstract:

Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV, IR, ect.), HR-ESI-MS techniques and chemical methods. Screening results indicated that compounds 4, 5, 12, 13 showed moderate neuroprotective effects on HO-induced cellular damage in human neuroblastoma SH-SY5Y cells (10 μM).

Article Published Date : Dec 31, 2017

Study Type : In Vitro Study

Additional Links

Substances : Panax Notoginseng : CK(225) : AC(100)

Diseases : Hydrogen Peroxide Induced Toxicity : CK(296) : AC(226)

Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(4396)

Additional Keywords : Hydrogen Peroxide Induced Toxicity, Neuroprotective Agents, Panax Notoginseng

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.

Printer-friendly version

Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells. - GreenMedInfo Summary

Print Options

Key Research Topics

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.