Article Publish Status: FREE
Abstract Title:

Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated fromRhizomes on Leukaemic Cells.

Abstract Source:

Molecules. 2020 Nov 23 ;25(22). Epub 2020 Nov 23. PMID: 33238470

Abstract Author(s):

Natsima Viriyaadhammaa, Aroonchai Saiai, Waranya Neimkhum, Wariya Nirachonkul, Wantida Chaiyana, Sawitree Chiampanichayakul, Singkome Tima, Toyonobu Usuki, Suwit Duangmano, Songyot Anuchapreeda

Article Affiliation:

Natsima Viriyaadhammaa


belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from, and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1)-1-heptene () and-1,7-diphenyl-5-hydroxy-1-heptene (). Compoundshowed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-inflammatory properties were stronger than those of compound. Compoundproved to be a potent antioxidant, compared to ascorbic acid. Neither compounds had any effect on red blood cell haemolysis. Furthermore, compoundsignificantly decreased Wilms' tumour 1 protein expression and cell proliferation in KG-1a cells. Compounddecreased the WT1 protein levels in a time- and dose- dependent manner. Compoundsuppressed cell cycle at the S phase. In conclusion, compoundhas a promising chemotherapeutic potential against leukaemia.

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