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Article Publish Status: FREE
Abstract Title:

Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated fromRhizomes on Leukaemic Cells.

Abstract Source:

Molecules. 2020 Nov 23 ;25(22). Epub 2020 Nov 23. PMID: 33238470

Abstract Author(s):

Natsima Viriyaadhammaa, Aroonchai Saiai, Waranya Neimkhum, Wariya Nirachonkul, Wantida Chaiyana, Sawitree Chiampanichayakul, Singkome Tima, Toyonobu Usuki, Suwit Duangmano, Songyot Anuchapreeda

Article Affiliation:

Natsima Viriyaadhammaa

Abstract:

belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from, and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1)-1-heptene () and-1,7-diphenyl-5-hydroxy-1-heptene (). Compoundshowed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-inflammatory properties were stronger than those of compound. Compoundproved to be a potent antioxidant, compared to ascorbic acid. Neither compounds had any effect on red blood cell haemolysis. Furthermore, compoundsignificantly decreased Wilms' tumour 1 protein expression and cell proliferation in KG-1a cells. Compounddecreased the WT1 protein levels in a time- and dose- dependent manner. Compoundsuppressed cell cycle at the S phase. In conclusion, compoundhas a promising chemotherapeutic potential against leukaemia.

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