Abstract Title:

[Regulation of protein kinases on signal pathway in breast cancer cell MCF-7 by curcumin].

Abstract Source:

Zhong Yao Cai. 2009 May;32(5):728-32. PMID: 19771847

Abstract Author(s):

Qian-Mei Zhou, Shi-Bing Su, Hui Zhang, Yi-Yu Lu

Article Affiliation:

Shanghai University of TCM, Shanghai 201203, China.


OBJECTIVE: To observe the effect of curcumin on protein kinases on cell signal pathway in breast cancer cell MCF-7.

METHODS: The suppressive effect of curcumin on MCF-7 cell proliferation as different concentration and at different time points were observed by MTT assay; The activity of p-ERK, p-NF-kappaB, p-p38 and p-JNK were observed by western blot.

RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK.

CONCLUSION: Curcumin can inhibit MCF-7 cell's proliferation, and its mechanism may be related to the activities of protein kinases on cell signal pathway.

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Sayer Ji
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