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Article Publish Status: FREE
Abstract Title:

Curcumin as an Epigenetic Therapeutic Agent in Myelodysplastic Syndromes (MDS).

Abstract Source:

Int J Mol Sci. 2021 Dec 30 ;23(1). Epub 2021 Dec 30. PMID: 35008835

Abstract Author(s):

Xiaoqing Xie, Daria Frank, Pradeep Kumar Patnana, Judith Schütte, Yahya Al-Matary, Longlong Liu, Lanying Wei, Martin Dugas, Julian Varghese, Subbaiah Chary Nimmagadda, Cyrus Khandanpour

Article Affiliation:

Xiaoqing Xie

Abstract:

Growth Factor Independence 1 (GFI1) is a transcription factor with an important role in the regulation of development of myeloid and lymphoid cell lineages and was implicated in the development of myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Reduced expression ofor presence of the(serine replaced with asparagine) variant leads to epigenetic changes in human and murine AML blasts and accelerated the development of leukaemia in a murine model of human MDS and AML. We and other groups previously showed that theallele or reduced expression of GFI1 in human AML blasts is associated with an inferior prognosis. Using,,mice and curcumin (a natural histone acetyltransferase inhibitor (HATi)), we now demonstrate that expansion oforleukaemic cells can be delayed. Curcumin treatment significantly reduced AML progression inormice and prolonged AML-free survival. Of note, curcumin treatment had no effect in,expressing mice. On a molecular level, curcumin treatment negatively affected open chromatin structure in theorhaematopoietic cells but notcells. Taken together, our study thus identified a therapeutic role for curcumin treatment in the treatment of AML patients (homo or heterozygous foror reducedexpression) and possibly improved therapy outcome.

Study Type : Animal Study

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