Abstract Title:

[Possible candidates for the compound which is expected to attenuate dioxin toxicity].

Abstract Source:

Fukuoka Igaku Zasshi. 2005 May;96(5):204-13. PMID: 15997774

Abstract Author(s):

Yuji Ishii, Takumi Ishida, Junpei Mutoh, Hideyuki Yamada, Kazuta Oguri

Article Affiliation:

Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.


This review deals with the three candidate compounds which may combat with dioxins' toxicity. Geranylgeranylacetone (GGA), an antiulcer drug, counteracts suppression of body weight gain and lethality produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice. Similarly, curcumin, a food ingredient anticipates the TCDD's toxicity on body weight gain. Both GGA and curcumin had no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that both compounds exhibit a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of aryl hydrocarbon receptor activation. Further, the mechanism involved in resveratrol action on dioxin's toxicity was also discussed. Prior to the application of these compounds to Yusho patients, the limitation and possibility of these candidate compounds are seemed to be further studied.

Study Type : In Vitro Study

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