Abstract Title:

Anti-arthritic actions ofβ-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro.

Abstract Source:

Biochem Biophys Res Commun. 2016 08 5 ;476(4):352-358. Epub 2016 May 27. PMID: 27240953

Abstract Author(s):

Keisuke Imada, Ayana Tsuchida, Kazunori Ogawa, Nidhi Sofat, Hideaki Nagase, Akira Ito, Takashi Sato

Article Affiliation:

Keisuke Imada


An inverse correlation between the morbidity of rheumatoid arthritis and daily intake ofβ-cryptoxanthin has been epidemiologically shown. In this study, we investigated the effects of β-cryptoxanthin on the metabolism of cartilage extracellular matrix in vivo and in vitro. Oral administration of β-cryptoxanthin (0.1-1 mg/kg) to antigen-induced arthritic rats suppressed the loss of glycosaminoglycans in articular cartilage, which is accompanied by the interference of aggrecanase-mediated degradation of aggrecan. Inhibition of the interleukin 1α (IL-1α)-induced aggrecan degradation by β-cryptoxanthin was also observed with porcine articular cartilage explants in culture. β-Cryptoxanthin (1-10 μM) dose-dependently down-regulated the IL-1α-induced gene expression of aggrecanase 1 (ADAMTS-4) and aggrecanase 2 (ADAMTS-5) in cultured human chondrocytes. Moreover, β-cryptoxanthin was found to augment the gene expression of aggrecan core protein in chondrocytes. These results provide novel evidence that β-cryptoxanthin exerts anti-arthritic actions and suggest that β-cryptoxanthin may be useful in blocking the progression of rheumatoid arthritis and osteoarthritis.

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