Abstract Title:

Inhibitory effect of chlorophyllin on the frequency of micronuclei induced by sodium nitrite in mice.

Abstract Source:

Phytother Res. 2002 Dec;16(8):754-7. PMID: 12458481

Abstract Author(s):

S Diaz-Barriga Arceo, A Hernández-Ceruelos, E Madrigal-Bujaidar, G Chamorro

Article Affiliation:

Laboratorio de Citogenética FESC-UNAM, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México.


In this report the potency of chlorophyllin (CHL) was evaluated to prevent two types of damage produced by nitrite in mice: the increase of micronucleated polychromatic erythrocytes (MNPE) and the bone marrow toxicity, measured as the index of polychromatic erythrocytes/normochromatic erythrocytes (PE/NE). The study was done in eight groups of male mice. The first three groups were administered orally for 4 days with sodium nitrite (10, 15 and 20 mg/kg), the daily administration with nitrite was followed by an intraperitoneal administration of CHL (4 mg/kg), three more groups were administered with the same amounts of nitrite, a seventh group of mice was treated with distilled water while another was treated with CHL (4 mg/kg). Our study produced two main results: (a) no bone marrow injury was induced by any of the tested chemicals, as indicated with the PE/NE index, and (b) CHL protected (as high as 44%) the MNPE produced in nitrite treated mice.

Study Type : Animal Study

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