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Abstract Title:

Chlorella vulgaris ameliorates testicular toxicity induced by carbon tetrachloride in male rats via modulating oxidative stress.

Abstract Source:

Andrologia. 2022 Jun 7:e14495. Epub 2022 Jun 7. PMID: 35671993

Abstract Author(s):

Akram Ranjbar, Mahtab Satari, Roohollah Mohseni, Alireza Tavilani, Hadi Ghasemi

Article Affiliation:

Akram Ranjbar

Abstract:

This study was aimed to evaluate the protective effects of Chlorella Vulgaris (CVE) (50 and 100 mg/kg doses) on sperm DNA fragmentation, testis oxidative stress in Carbon tetrachloride (CCL4)-exposed rats. Thirty healthy male Wistar rats were divided into five groups (n = 6): Control; CCl4; CVE; CCl4 + CVE50; CCl4 + CVE100. At the end of the experiment, the testicular oxidative stress parameters were estimated. The Chromomycin A3 (CMA3) and Acridine orange (AO) staining were performed to examine the sperm DNA fragmentation status. CCl4 treatment showed a significant decrease in antioxidant markers and sperm count, viability, normal morphology and motility as well as significantly increased the testicular oxidative stress markers, and the percentage of CMA3 and AO positive sperms in normal rats (p < 0.05). While CVE supplementation has revealed a significant decrease in the percentage of CMA3 and AO positive sperms as well as testicular oxidative stress markers and considerably improved the testis antioxidant status (p < 0.05). CVE has also increased the number of sperms with forwarding movement, normal morphology and viability (p < 0.05). Taken together, our analyses suggest that CVE may play a critical role in attenuating the CCl4-induced oxidative stress in the testis, thereby protecting the sperm membrane and DNA against oxidative damage.

Study Type : Animal Study

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