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Abstract Title:

Cellular and molecular mechanisms of curcumin on thyroid gland disorders.

Abstract Source:

Curr Med Chem. 2022 Feb 10. Epub 2022 Feb 10. PMID: 35142266

Abstract Author(s):

Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

Article Affiliation:

Farzaneh Shakeri

Abstract:

There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin has been used widely in Ayurvedic and Chinese medicine for various conditions. The role of curcumin on thyroid glands has been shown by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. We reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the thyroid gland therapeutic effect of curcumin.

Study Type : Review

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